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KMID : 0377619750290050471
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Korean Jungang Medical Journal
1975 Volume.29 No. 5 p.471 ~ p.474
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Clinical Observation of Sulfobenzylpenicillin in Severely Infected Surgical Patients
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Abstract
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Sulbenicillin is similar to ampicillin or carbenicillin in its chemical structure and its antibacterial activities. This compound is more effective against penicillinase producing organisms and gram negative organisms. In additions, it is effective against pseudomonas and proteus groups like carbenicillin.
Our clinical studies were performed on 19 patients who admitted to our surgery department due to severe infection(Tab. 1).
In this studies, the causative organisms were divided into 7 groups; E. coli (6), pseudomonas (5), klebsiella (4), coagulase positive staphylococus (4), preteus (3), gram negative bacilli (3) and flabobacter (1) (Tab. 2).
Sulbenicillin was administered either I. M. or I. V. 2 to 4 gm per day for 3 to 14 days in these severely infected patients.
Results are as following;
1) Infection due to E. coli, gram negative bacilli, and coagulase positive staphyl￢ococci was well controlled with sulbenicillin administration within 1 week. Results were all excellent.
2) Infection due to pseudomonas and proteous groups were relatively well controlled within 7 to 14 days administration.
Results were good in 6 cases and poor in 1 case.
3) Infection due to klebsiella was unfortunately resistant to the sulbenicillin. 4) Over-all cure rate was about 79%.
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